Sequence information transfer using covalent template-directed synthesis

Template-directed synthesis of mechanically interlocked molecular bundles using dynamic covalent chemistry.

Mixing the dipyrido[24]crown-8 derivatives carrying one or two formyl group(s) on the 4 position(s) of their pyridine ring(s) with a 3-fold symmetrical trisammonium ion template in a 3:1 ratio in CD3NO2 results in the formation of thermodynamically stable [4]pseudorotaxanes which, upon addition of a 1,3,5-trisaminobenzene cap, form mechanically interlocked molecular bundles with one and two cap...

Template-directed synthesis of metal-organic materials.

This tutorial review details the emergence of template-directed synthesis of metal-organic materials (MOMs) with emphasis upon reports of MOMs in which the template is retained, template@MOMs, and structurally characterized. Such MOMs enable analysis of the nature of the intermolecular interactions that occur between the template and the resulting host framework. The utilization of such underst...

Rate in template-directed polymer synthesis.

We discuss the temporal efficiency of template-directed polymer synthesis, such as DNA replication and transcription, under a given template string. To weigh the synthesis speed and accuracy on the same scale, we propose a template-directed synthesis (TDS) rate, which contains an expression analogous to that for the Shannon entropy. Increasing the synthesis speed accelerates the TDS rate, but t...

Information transfer from peptide nucleic acids to RNA by template-directed syntheses.

Peptide nucleic acids (PNAs) are uncharged analogs of DNA and RNA in which the ribose-phosphate backbone is substituted by a backbone held together by amide bonds. PNAs are interesting as models of alternative genetic systems because they form potentially informational base paired helical structures. A PNA C10 oligomer has been shown to act as template for efficient formation of oligoguanylates...

Site-Directed Covalent Immobilization